NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells.

Nat Genet · 2015 · PMC4449308 · PMID 25938942

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highly significantp = 1.4 × 10 −22actually significant

This revealed a highly significant relationship between the level of methylation of the CASP1 promoter and CASP1 mRNA expression in ALL cells (p = 1.4 × 10 −22 ; Fig. 1F , Supplementary Fig. 2 panels A–C ).

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