Barely Significant
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Endogenous opioid antagonism in physiological experimental pain models: a systematic review.

PLoS One · 2015 · PMC4452333 · PMID 26029906

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highly significantno p-value reported
The authors observed highly significant sequence effects: subjects randomized to receive placebo at their first session (naloxone administered at the second and third sessions) demonstrated a higher difference in pain scores compared to the naloxone sessions, than when placebo was administered at the third session (naloxone administered at the at the first and second sessions).

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