Transcription addiction: can we garner the Yin and Yang functions of E2F1 for cancer therapy?

17 In lung cancer, highly significant association between E2F1 and the ATP-binding cassette sub-family G member 2 has been found implying that E2F1 could temper response to chemotherapeutic drugs. 18 Interestingly, E2F1 overexpression is frequently found in NSCLC and E2F1-inducible miR-449 has a tumor suppressive role 19 although, there is no correlation between E2F1 protein expression and clinical outcome including progression-free survival. 20 Considering the double-edged role of E2F1 in regulating cellular growth and death homeostasis, the actual effects that E2F1 may have on human malignancies can be difficult to predict.

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