Perinatal risk factors for premature ischaemic heart disease in a Swedish national cohort.

Further adjustment for gestational age at birth, sociodemographic factors, comorbidities and parental history of IHD resulted in a moderately attenuated risk estimate that remained highly significant (fully adjusted HR for <−2 SD vs −1 to <1 SD, 1.54; 95% CI 1.15 to 2.07; p=0.004), and an inverse trend remained across the full range of fetal growth (fully adjusted HR per additional 1 SD, 0.93; 95% CI 0.87 to 0.99; p=0.04) ( table 1 , adjusted model 2).

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