Investigation of sex differences in the expression of RORA and its transcriptional targets in the brain as a potential contributor to the sex bias in autism.

Analysis of Rora and transcriptional target gene expression in the frontal cortex and cerebellum of wild-type male and female C57BL/6 mice Because the genetic heterogeneity of human subjects most likely influences gene expression [ 38 ], thus rendering direct comparisons of expression data from a limited number of postmortem samples (n = 3 to 6) insignificant or at best marginally significant, we conducted pilot studies with male and female wild-type C57BL/6 mice to address the question of sexually dimorphic expression of Rora and that of several of its validated transcriptional targets [ 33 ].

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