Developmental Expression and Hypoxic Induction of Hypoxia Inducible Transcription Factors in the Zebrafish.

Embryos incubated in hypoxia starting at 28 h after fertilization showed an increase in Hif-1α protein after 4 h of hypoxia, and a 4 h hypoxic incubation, started at 52 h after fertilization, resulted in a more than two-fold increase in Hif-1α protein concentration, which was highly significant.

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