Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition.

Indeed, there was a highly significant overlap between BRAT-associated mRNAs as defined by our RIP-Chip experiment and transcripts upregulated in brat mutant embryos at 1.5 to 3.0, 3.0 to 4.5, and 4.5 to 6.0 h (Figure 7B to D , Table 4 , Bonferroni-corrected Fisher’s exact test P values ranged from 6.6 × 10 −12 to 5.7 × 10 −20 ).

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