A novel anti-inflammatory natural product from Sphaeranthus indicus inhibits expression of VCAM1 and ICAM1, and slows atherosclerosis progression independent of lipid changes.

Nutr Metab (Lond) · 2015 · PMC4462118 · PMID 26064179

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highly significantno p-value reported

Prospective evidence provided by the JUPITER trial (Justification for the Use of Statins in Primary Prevention: an Intervention Trial Evaluating Rosuvastatin) demonstrated that patients with normal LDL-C levels but elevated hsCRP levels showed highly significant (-44 %) reduction in adverse cardiovascular events [ 17 ], suggesting additional benefit of hsCRP reduction and demonstrating an inflammatory component in the CVD risk.

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