Adverse childhood experiences are associated with spontaneous preterm birth: a case-control study.

BMC Med · 2015 · PMC4464612 · PMID 26063042

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highly significantno p-value reported

More importantly, being exposed to two or more ACEs prior to the age of 18 was associated with a highly significant two-fold increase in the risk of delivering an infant preterm.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.