Clinical data analyses showed the lower expression of FBXW7 significantly correlated with metastasis, TNM stage and differentiation in both IHCC and PHCC, however, only a statistical trend was found in DCC, which may be due to the absence of more advanced (stage III and stage IV) tumor specimens in the dataset we analyzed (Table 1 ).
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FBXW7 suppresses epithelial-mesenchymal transition, stemness and metastatic potential of cholangiocarcinoma cells.
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