Barely Significant
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Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis.

PLoS One · 2015 · PMC4467867 · PMID 26075887

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highly significantno p-value reported
The expression of APOE, a key lipoprotein and carrier of cholesterol in the brain, has been shown to be a highly significant risk factor in the development of late-onset AD [ 23 , 80 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.