Some of the proposed mechanisms include mechanical injury to the tubules caused by myoglobin precipitation, direct toxic effect of free chelatable iron on tubules, and hypovulemia.[ 13 22 ] It has been shown that the amount of myoglobin released in the blood correlates with serum CK and consequently to ARF.[ 23 ] Therefore, higher levels of CK should be present in the setting of ARF.[ 24 ] Indeed, our findings of the highly significant positive correlation between serum creatinine values (as a marker of renal function) and CK values are compatible with this explanation.
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