The DAXX co-repressor is directly recruited to active regulatory elements genome-wide to regulate autophagy programs in a model of human prostate cancer.

Autophagy genes, including DAPK3 and ULK1, which were previously shown to be DAXX repression targets [Submitted], were found to be closer to DAXX ChIP-Seq peaks than all other genes combined (Figure 3 ), implying that they are very likely to be regulated by DAXX (with the difference being highly significant: p < 10 −7 ).

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