Circulating cell-free DNA and its integrity as a prognostic marker for breast cancer.

Further, an increasing trend of DNA integrity was observed from healthy controls (0.35 ± 0.27) to breast cancer stages of I–III (0.53 ± 0.23) to stage IV cases (0.60 ± 0.26).

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One study has reported a borderline significance between the plasma tumor DNA and DFS in multivariate analysis with tumor size, lymph node and tumor stage (Silva et al. 2002b ).

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When each patient was categorized as high or low based on the median levels of each biomarker among alive patients, only ALU115 showed marginally significant association with OS.

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