Immune Pathways in Atopic Dermatitis, and Definition of Biomarkers through Broad and Targeted Therapeutics.

A number of correlations with disease activity unique to either of these subtypes were found, including CCL20, IFN-α, and IL-1β, which only correlate with disease activity in intrinsic lesions, while serum IgE levels (highly significant), the Th2-cytokines (IL-4, IL-5), as well as the Th2-promoting cytokines (IL-21 and IL-19) were associated with disease activity in extrinsic lesions only ( Table 1 ).

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