Marginal significance was observed in PRAD (p-value = 0.01) and HNSC (p-value = 0.04), while highly statistical significance was detected in COADREAD, LUAD and LUSC (p-value = 3.82e-13, 1e-15 and 4.04e-16 respectively) (Figure 1 ).
Compared to RBPs, TFs only showed marginally significant enrichment in HNSC, possibly due to the fact that the activity changes of TF are at the protein level which cannot be reflected at the transcription level (Figure 1 ). lncRNAs were significantly depleted across all cancer types (Figure 1 ), which are possibly biased because only 264 of 9227 lncRNAs were included in the standardized mRNA-Seq data in Firehose (see Materials and Methods).