Defining the Pharmacodynamic Profile and Therapeutic Index of NHS-IL12 Immunocytokine in Dogs with Malignant Melanoma.

PLoS One · 2015 · PMC4474860 · PMID 26091536

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an overall trendno p-value reported

Immunohistochemical analysis of tumor biopsies revealed an overall trend towards increased CD8 + T-cell infiltration following treatment with NHS-IL12, possibly the result of IL-12-induced T-cell proliferation [ 28 , 29 ].

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