Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target.

Although this dataset does not contain survival data, the correlations between SPR expression and three important clinical NB parameters are highly significant (Fig. 2 , a-c ): age at diagnosis ( P = 1.9 · 10 −23 , MYCN tumor amplification ( P = 7.9 · 10 −15 , and INSS stage (various P values < 0.05).

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