It can be concluded from the above that double substitution (CC) is a highly significant risk factor against homozygous common (GG) and heterozygous genotypes (GC); however, heterozygous does not appear to be a significant risk factor against homozygous common genotype.
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RAD51 135G>C substitution increases breast cancer risk in an ethnic-specific manner: a meta-analysis on 21,236 cases and 19,407 controls.
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