The results of this study clearly demonstrate that DRα1-mMOG-35-55 treatment of EAE in C57BL/6 mice produced a highly significant reduction of CNS inflammation, mainly by inhibiting the infiltration of pro-inflammatory cells from the periphery.
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HLA-DRα1-mMOG-35-55 treatment of experimental autoimmune encephalomyelitis reduces CNS inflammation, enhances M2 macrophage frequency, and promotes neuroprotection.
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