Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes.

This effect, however, was modest (+15%, days 4 and 8) and diminished to a statistical trend at later time-points (p = 0.09, days 12 and 18; Figure 3 B). 3.4 Effects of chronic FGF21 treatment on white and brown adipocyte marker gene expression Chronic rhFGF21 treatment significantly impaired the expression of the key adipogenic transcription factors peroxisome proliferator-activated receptor-γ (PPAR-γ; -15%, day 18; Figure 4 A) and CCAAT/enhancer-binding protein-α (C/EBP-α; up to −40%, days 8–18; Figure 4 B).

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