Thus, growth arrest of sarcomas in vivo induced senescence and was associated with restoration of the cell-fate specific markers of myocytes, the origin of A204 RMS. In vitro , growth arrest of A204 sarcoma cells induced by IFN-γ and TNF was accompanied by an immediate and highly significant increase (10-fold compared to untreated control) of cyclin dependent kinase inhibitor p21 CIP1/WAF1 , 27,28,31,32 which in skeletal muscle intrinsically withdraws the cells from cycling 26 ( Fig. 7A ).
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Cancer-targeted IL-12 controls human rhabdomyosarcoma by senescence induction and myogenic differentiation.
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