Epigenetics of Notch1 regulation in pulmonary microvascular rarefaction following extrauterine growth restriction.

Although no significant difference was found at other CpG sites, compared with control rats, more than half of these sites showed a slight trend toward hypermethylation, such as the −2639 and −2446 sites, in the EUGR rats, suggesting a general trend of hypermethylation of this locus at the distal promoter of the Notch1 gene.

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