Nicotinic receptors in non-human primates: Analysis of genetic and functional conservation with humans.

Neuropharmacology · 2015 · PMC4486519 · PMID 25661700

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a slight trendno p-value reported

In preliminary studies, no significant differences between cynomolgus α5 404Ala and wild-type α5 were seen, though a slight trend towards increased maximal response was observed.

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highly significantno p-value reported

The subject of genetic diversity within humans is highly significant as single nucleotide polymorphisms (SNPs) provide key insights into gene function, pathophysiology, and can greatly influence individual responses to therapeutics.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.