Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.

3b ) and a meta-analysis of the two agents revealed highly significant decreases ( P <0.01, n =25, one-sided analysis of variance (ANOVA), percentages±s.d.; statistical details in Fig. 3 legend and Methods) in the αS60:14 ratio for A30P (77.5±15.5% of WT, that is, a 22.5% decrease), E46K (61.7±10.1% of WT, a 38.3% decrease), G51D (47.8±10.0% of WT, a 52.2% decrease) and A53T (66.5±10.4% of WT, a 33.5% decrease).

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