highly significantp < 0.00001
This dichotomy between the effects of HP1E depletion on the euchromatic and heterochromatic compartment is highly significant (p < 0.00001) and suggests a direct action of HP1E in the heterochromatic compartment, akin to its closest HP1 relative, HP1A ( Kellum et al., 1995 ; Levine et al., 2012 ).