The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition.

85 , 86 The possibility that such an oxidative attack would strike late in spermatogenesis, when sperm differentiation is occurring, is suggested by a highly significant under-representation of phosphoglycerate kinase (PGK), mirroring the loss of HSPA2, in spermatozoa exhibiting an inability to bind to the ZP. 26 The significance of this finding is that the PGK isoform in spermatozoa (PGK2) is transcribed late in spermatogenesis to become the major PGK in spermatozoa. 87 The loss of this protein is therefore consistent with the disruption of protein translation during spermiogenesis, as the PGK2 mRNA migrates from RNP to polysomes, because of oxidative damage to the mRNA and/or disruption of the translation machinery itself.

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