However, the data showed a positive trend for the secondary end points, including change from baseline in best visual acuity and change in visual acuity for both eyes, particularly for patients with discordant visual acuities. 92 The study also found the largest treatment effect for patients with the 11778 or 3460 mutation, while those with the 14484 mutation had a high spontaneous recovery rate in the placebo group, thought to abolish any treatment effect.
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