Endogenous GLP-1 as a key self-defense molecule against lipotoxicity in pancreatic islets.

Nonetheless, the GLP-1 levels at 72 h in both the cell medium and the cell lysates were almost equivalent to those at 48 h and even showed a decreasing trend ( Fig. 2A and B ), which may be due to the severe serious injury induced by 72 h of exposure to palmitate ( Fig. 1A and B ; increased apoptosis and decreased cell viability).

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