With regard to OS, a trend towards significance in favor of patients with an PMA ≥ 0.36 and ACM=0 (median OS not reached; 1-year OS 86.0%, 2-year OS 68.6%) in comparison with patients with an EGFR PMA < 0.36 and ACM ≥ 1 (median OS 4.0 months, 95% CI 1-18; 1-year OS 50.5%, 2-year OS 25.0%) was found (p0.06), with a HR of 4.01 (95% CI 0.78-20.59, p=0.10) (Figure 3 , Panel D).
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Molecular heterogeneity assessment by next-generation sequencing and response to gefitinib of EGFR mutant advanced lung adenocarcinoma.
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Our results support this hypothesis, although, given the limited number of patients, only a weak trend in favor of those patients with a high PMA (≥ 0.36) was found.
A borderline significant difference in favor of the 8 patients with ACM=0 (median PFS 12.3 months, 95% CI 6.1-18.6; 1-year PFS 61.5%, 2-year PFS 31.3%) in comparison with those 9 with a ACM≥1 (median PFS 3.0 months, 95% CI 0.7-5.3; 1-year PFS 22.0%, 2-year PFS 11.1%) was found (p=0.03), with a HR of 2.88 (95% CI 0.92-9.02; p=0.068) (Figure 2 , Panel C).