Neonatal lethal Costello syndrome and unusual dinucleotide deletion/insertion mutations in HRAS predicting p.Gly12Val.

Am J Med Genet A · 2012 · PMC4495255 · PMID 22495892

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may be significantno p-value reported

It is also possible that there may be significant prenatal lethality associated with severe HRAS mutations, during either embryonic or fetal development, which would further hinder recognition of the full phenotypic spectrum associated with such alleles.

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