Assessment of incidental findings in 232 whole-exome sequences from the Baylor-Hopkins Center for Mendelian Genomics.

However, the ACMG recommendations currently apply only to SNVs and indels, so this additional variation—some of which may be significant—would not be considered under the current guidelines. 1 Based on this experience, we suggest that clinicians and researchers interested in returning incidental variants found by next-generation sequencing adopt a uniform, well-defined set of criteria for variant classification.

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