Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase.

J Antimicrob Chemother · 2015 · PMC4498294 · PMID 25656411

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a positive trendno p-value reported

A positive trend ( r = 0.549) between the enzymatic inhibition of Mtb-MurE (IC 50 ) and the growth inhibition of M. tuberculosis H 37 Rv (MIC) was observed for eight THIs, which had IC 50 and MIC values in the range 40–400 μM.

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