Changes in the Incidence of Congenital Anomalies in Henan Province, China, from 1997 to 2011.

PLoS One · 2015 · PMC4498818 · PMID 26161554

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an increasing trendno p-value reported

In our investigation, the average ratio of maternal age less than 20 years was 0.9%; this ratio showed an increasing trend and reached the highest point (1.7%) in 2011.

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a decreasing trendno p-value reported

The incidence of chromosomal aberrations exhibited a decreasing trend, which was probably related to the introduction of advanced noninvasive prenatal diagnostic methodology with subsequent induced abortion [ 37 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.