of borderline significancep = 0.078
In all treated individuals, changes in HbA 1c across time were of borderline significance (F = 2.70, p = 0.078), while changes in total cholesterol, LDL-cholesterol and triglycerides reached significant and clinically meaningful improvement during the 1-year follow-up (F = 11.64, p < 0.001; F = 6.50, p = 0.002; and F = 6.58, p = 0.003, respectively).