Additive Effects of Retinoic Acid (RA) and Bone Morphogenetic Protein 4 (BMP-4) Apoptosis Signaling in Retinoblastoma Cell Lines.

PLoS One · 2015 · PMC4501735 · PMID 26173116

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In contrast to former findings [ 45 ], we did not detect an increase in full caspase-9 transcript levels upon administration of RA, BMP-4 or RA/BMP-4 double treatment ( S10 Fig ), however, observed a highly significant increase in caspase-9 cleavage activity following RA and BMP-4 administration, which was further increased by RA/BMP-4 double treatment.

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