The module displayed a highly significant 20-fold enrichment for microglial markers compared with random gene sets of identical size (40 of 162 microglia markers, compared with a median of 2 expected by chance, empirical p -value < 0.001); moreover, it contained only 1 of the n = 29 markers specific for neurons, oligodendrocytes, endothelial cells, or astrocytes.
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Microglia recapitulate a hematopoietic master regulator network in the aging human frontal cortex.
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