Results Effect of the multi-copy transgene on viability of non-chimaeric Tg/ − and Tg/Tg mice Hemizygous Tg/ − mice were produced at the expected Mendelian frequencies in reciprocal Tg/ − × − / − crosses but there was a non-significant trend for fewer than expected Tg/Tg homozygotes in reciprocal Tg/Tg × Tg/ − crosses and this was highly significant in Tg/ − × Tg/ − crosses (Online Resource 1; Supplementary Table S1).
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Lessons from mouse chimaera experiments with a reiterated transgene marker: revised marker criteria and a review of chimaera markers.
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