By 6 days after RNAi, we observed highly significant increases in the number of piwi-1 + stem cells in mex3-1(RNAi) animals compared to controls, which rose to a 50% increase by day 12 ( Figure 5C , Figure 5—figure supplement 1 ).
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A mex3 homolog is required for differentiation during planarian stem cell lineage development.
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