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Genetic Characterization of a Novel HIV-1 Circulating Recombinant Form (CRF74_01B) Identified among Intravenous Drug Users in Malaysia: Recombination History and Phylogenetic Linkage with Previously Defined Recombinant Lineages.

PLoS One · 2015 · PMC4510129 · PMID 26196131

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an increasing trendno p-value reported
More recently, a new CRF candidate closely related to CRF33_01B was also detected through molecular screening [ 11 ], indicating an increasing trend of second-generation CRFs emerging in the region.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.