Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice.

Dietary rapamycin reduced developmental weight gain in a dose-dependent manner in control animals, with strength of effect ranging from no observed impact at 14 PPM (data not shown), to a robust and highly significant reduction in body size at 378 PPM that is similar in magnitude to what we previously reported for daily injection of 8 mg/kg (Figure 2 ).

also in 132,142 other papers