borderline significantP = 0.067
Effects of Metabolite-Associated SNPs on Metabolic Traits In linear regression analysis adjusted for age, sex, and BMI, the major allele of rs2431332 (associated with lower DMG levels) showed significant direct relationships with insulin (β = 0.047, P = 0.019) and the HOMA-index (β = 0.046, P = 0.019) and a borderline significant association with glucose (β = 0.040, P = 0.067).