Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.

Intranigral injection of AAV-hα-syn resulted in a markedly significant reduction of dopaminergic fibers, evidenced by a reduction of TH (Fig. 1a and f , Additional file 5 : Figure S1a) and DAT (Fig. 1b and f , Additional file 5 : Figure S1b) immunostaining, beginning at 1 week and reaching a plateau at 4 weeks, associated with progressive dopamine neuron death ranging from 50 % at 1 week to approximately 80 % at 16 weeks after surgery (Fig. 1d and f , Additional file 5 : Figure S1c).

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