Differential transcriptomic and metabolic profiles of M. africanum- and M. tuberculosis-infected patients after, but not before, drug treatment.

Further analysis of the gene set revealed a highly significant enrichment (p= 1.0 −7 ) for the upstream regulator hepatocyte nuclear factor 4 alpha (HNF4α), which regulates almost 200 genes (~ 15% of genes) in the list of differentially expressed genes between the two groups post-treatment ( Supplementary Table 1B ).

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