It has been proposed that iron may affect cellular oxygen-sensing pathways, but the role of iron under cellular-specific mechanism is unknown; previous studies have found a high expression of the HIF-regulated gene products VEGF and nitric oxide synthase in AMS patients, suggesting a highly significant association between iron and AMS [ 23 , 24 ].
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Effect of Intravenous Iron Supplementation on Acute Mountain Sickness: A Preliminary Randomized Controlled Study.
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