Synthetic RNAs Mimicking Structural Domains in the Foot-and-Mouth Disease Virus Genome Elicit a Broad Innate Immune Response in Porcine Cells Triggered by RIG-I and TLR Activation.

At both RNA concentrations assayed, pDC-enriched PBMCs induced 10 to 19-fold higher levels of IFN-α upon transfection, with statistically highly significant differences ( p < 0.0001) in all cases; in the case of the S transcript, those levels were 1.5 higher when the dose was increased from 5 to 20 μg/mL.

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