The Mechanisms of Human Renal Epithelial Cell Modulation of Autologous Dendritic Cell Phenotype and Function.

Although PTEC-MoDC from CI cultures stimulated higher levels of T cell proliferation compared to PTEC from CD co-cultures, suggesting a partially contact-mediated mechanism for PTEC suppression ( Fig 3 ), this failed to reach significance.

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However, we observed partial restoration of CD4 + T cell proliferation in four out of five donors ( Fig 7 ) when PTEC-MoDC were differentiated in the presence of 1-MT, although this restoration did not achieve significance.

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