rs10235235 was originally identified on the basis of a highly significant association with hormone levels, accounting for 4.9% of the variation in premenopausal urinary oestrone glucuronide levels [ 19 ].
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Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study.
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There was, however, marginally significant evidence that the genotypic OR estimates departed from those expected under a multiplicative model with the inverse association of the GG genotype being more than the square of that of the AG genotype (test for deviation from multiplicative model, P = 0.04).