highly significantp = 9*10 −15
Inversely, a statistically highly significant DEHP-induced decreased reads numbers (p = 9*10 −15 ) was observed in Tmem125 promoter region in MBDseq experiment in C57BL/6J controls (19.8±3.9) compared with DEHP300 (0.9±3.9%), ( Fig 5B ), consistent with a DEHP-induced decreased methylation levels recorded in pyrosequencing experiment in CpG 1 although not statistically significant (p = 0.7) in C57BL/6J controls (69±4%) compared to DEHP300 (65±10%), ( Fig 5C ).