almost significantP = 0.070
A Cox-model for DDFS with the three main effects for ER, PAR-1 and PAR-2, the three two-way interaction terms ER*PAR-1, ER*PAR-2 and PAR-1*PAR-2, and finally a term ER*PAR-1*PAR-2 for the three-way interaction, suggested a three-way interaction, which was almost significant (P = 0.070).